The BREAKING-ICE App© V2.0 is out! Enjoy automated explorations and a new companion KM digitizer App.

Discover “Automated” modes. Discover the brand-new, user-friendly, Assistant-KM-BREAKING-ICE© app, which allows you to extract and directly explore data within the BREAKING-ICE App© V2.

In a given trial, informative censoring can create or amplify an apparent treatment effect that would not have been observed without informative censoring. Informative censoring, when occurring in a trial, questions the validity of the results as reported. Informative censoring remains a neglected cause of bias; nevertheless, it receives increased attention.

The BREAKING-ICE App© starts from Kaplan–Meier curves reconstructed from pseudo individual-level data (pseudo-IPD) using the IPDfromKM package and data extracted from original curves. These are not real patient data: they are numerical estimates consistent with published curves and tables, used to explore informative censoring through sensitivity analyses. Upstream file preparation can be performed with Assistant-KM-BREAKING-ICE©.

A central goal of the BREAKING-ICE App© is to visually and instantaneously explore how alternative assumptions about censoring may affect curves and statistical outputs. The BREAKING-ICE App© has been published in The Lancet Oncology, June 2025, available here.

The BREAKING-ICE App© V2 is available here.
The brand-new Assistant-KM-BREAKING-ICE© is available here.

Both come with a user guide, and a video tutorial will be available soon. Please let me know what you think!