love these thought provoking articles... I save every one and flip through them occasionally to think about them and formulate ideas/questions whenever I see a trial
Thank you for a very interesting article (and proposal).
Of course, this highlights a more general observation which is that “adaptive” trial designs (by which I mean those in which randomization algorithms are tweaked continuously according to results accruing in real-time) are, in general, underutilized.
The main roadblocks to their use, lack of reliable communications and centralized computerized management systems, no longer exist.
Yet such designs can potentially shorten trials significantly and / or reduce the numbers required, and / or make some otherwise difficult trials (because of recruitment) easier to perform.
love these thought provoking articles... I save every one and flip through them occasionally to think about them and formulate ideas/questions whenever I see a trial
Thank you!
Thank you for a very interesting article (and proposal).
Of course, this highlights a more general observation which is that “adaptive” trial designs (by which I mean those in which randomization algorithms are tweaked continuously according to results accruing in real-time) are, in general, underutilized.
The main roadblocks to their use, lack of reliable communications and centralized computerized management systems, no longer exist.
Yet such designs can potentially shorten trials significantly and / or reduce the numbers required, and / or make some otherwise difficult trials (because of recruitment) easier to perform.