Not a patent protected drug, but here’s an example. Despite the claim of similar side effect profiles, I suspect AE’s could be lower with alternate day dosing.
Double-blind, Randomized Trial of Alternative Letrozole Dosing
Regimens in Postmenopausal Women with Increased Breast
PD-1 inhibitors can be used at fractio of a dose. Low-dose immunotherapy has been shown to have efficacy in HNSCC and breast cancer.
Not a patent protected drug, but here’s an example. Despite the claim of similar side effect profiles, I suspect AE’s could be lower with alternate day dosing.
Double-blind, Randomized Trial of Alternative Letrozole Dosing
Regimens in Postmenopausal Women with Increased Breast
Cancer Risk
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740217/pdf/nihms745043.pdf
Never implemented.